SEN 12333

CAS No. 874450-44-9

SEN 12333( —— )

Catalog No. M24888 CAS No. 874450-44-9

α7 nicotinic acetylcholine receptor (nAChR) agonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 35 In Stock
5MG 58 In Stock
10MG 87 In Stock
25MG 177 In Stock
50MG 288 In Stock
100MG 478 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    SEN 12333
  • Note
    Research use only, not for human use.
  • Brief Description
    α7 nicotinic acetylcholine receptor (nAChR) agonist.
  • Description
    α7 nicotinic acetylcholine receptor (nAChR) agonist.
  • In Vitro
    In whole-cell patch-clamp recordings, SEN12333 activates peak currents and maximal total charges similar to acetylcholine (EC50= 12 μM). SEN12333 displays functional antagonism at histamine H3?receptors (IC50=103 nM) and weak agonist activity at human ganglionic?α3 nAChRs (IC50=8.5?μM).
  • In Vivo
    SEN12333 (intraperitoneal?injection; 3 mg/kg) improves episodic memory in a novel object recognition task in rats in conditions of spontaneous forgetting as well as cognitive disruptions induced via glutamatergic or cholinergic mechanisms. SEN12333 also prevents a scopolamine-induced deficit in a passive avoidance task.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    AChR
  • Recptor
    α7 nAChR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    874450-44-9
  • Formula Weight
    339.43
  • Molecular Formula
    C20H25N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:<33.94mg/ml
  • SMILES
    O=C(CCCCN1CCOCC1)Nc(cc1)ccc1-c1cnccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
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